Challenging the concept of diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama disease).

Diffuse neurofibrillary tangles with calcification: a new presenile dementia.

The term "diffuse neurofibrillary tangles with calcification" (DNTC) is proposed for a new form of presenile dementia. It is characterised by slowly progressive cortical dementia in the presenium, localised temporal or temporofrontal lobar atrophy, numerous neurofibrillary tangles widespread in the cerebral cortex, and pronounced calcareous deposits; 16 cases of DNTC, have been reported.

Masaya Mukai and Keigo Shibayama

1016Surgical Site Infection Risk Stratification for Kidney Surgery: Use of Endoscopy as an Effect Modifier

Endoscopy as an Effect Modifier Takuya Yamagishi, MD, PhD; Satowa Suzuki, MD, PhD; Mayumi Aminaka, RN, PhD; Atsuko Tsutsui, MD, PhD; Keita Morikane, MD, PhD; Keigo Shibayama, MD, PhD; Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan; National Institute of Infectious Diseases, Tokyo, Japan; National Institute of Infectious Diseases, Shinju...

Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains.

The two pathognomonic lesions in the brain of AD patients are senile plaques and intraneuronal neurofibrillary tangles (NFT). Previous studies have demonstrated that amyloid-β (Aβ) is a component of both senile plaques and NFTs, and have showed that intracellular accumulation of Aβ is toxic for cells and precedes the appearance of extracellular amyloid deposits. Here we report that there are nu...

Vitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease

Objective(s): Vitamin E may have beneficial effects on oxidative stress and Aβ-associated reactive oxygen species production in Alzheimer’s disease. But, the exact role of vitamin E as a treatment for Alzheimer’s disease pathogenesis still needs to be studied. Hence, we examined the therapeutic effects of vitamin E on the density of congophilic amyloid plaques and neur...